I play straight into the amp, no effects.
I use a lespaul studio with burstbuckers pro, a lespaul Menace, an SG faded equipped with 498/490, a LTD H400 with EMGs and a Yamaha RGX-A2 all through a Recto-Verb II with a 2X12 3/4 back and a 2X12 Recto cab.
I mostly play my own stuff, but also some Sabbath, Priest, LedZep, etc...
Sometimes, maybe once or twice a year, I get an itch and I use a Digitech Delay and/or a Dunlop Cry Baby for an hour or two.
Then I get fed up of them and put them away and go back to guitar and amp only.
Sometimes I hit a chord or a single note and I just stop playing and let it ring and my mind goes like a screensaver and I just "listen" for a little while. Gives me goosebumps over my goosebumps. That's one of those things that makes having a Mesa so gratifying.