Hi gsouth,
I play on the UK Gospel scene playing small chapels, through TV studios to auditoriums and outdoor venues. I play in a weekly service in a hall seating around 400, and a monthly service in a modern church seating 5-600, but I have often used my F-50 in auditoriums seating 1700 and more. I've never run out of power or clean headroom, even on the outdoor gigs. Nevertheless, you should know that I usually mike my combo, and let the PA provide the even spread - however, I have no problems at all humbling and subduing the volume of a drummer or bassist.
I use a G-Major in the F-50's loop, not just for FX, but also to provide attenuation in the loop, allowing me to turn up the Master Volumes, and open up the amp's front end more, and get great tone at any volume. I also have wired a custom cable to allow the G-Major to control the channel switching on my F-50, thus allowing me to select a tone (both amp channel and FX) with a single stomp on my MIDI footswitch. This makes for an effortlessly flexible live rig.
In terms of musical style, modern Gospel calls on tones from jazz and blues, through rock and hard rock. Versatility may be the least of your worries with the F-series, though. If you haven't already discovered it, check out
the F-series Lounge over at HCAF, where you'll find players from Motown to Progressive Metal. You can find some clips of my F50 in
this thread,
Big smiles,
Andy.