Is your impedance set correctly on the selection of impedance switch when running the combo w/ the 4x12"?
Meaning, say your combo (2x12") is running at 16 ohms and the 4x12" running also at 16 ohms too, in parallel, your output transformer tap (switch) should be set at 8 ohms.
Now if your combo's speakers is at 8 ohms (2-16 ohms speakers, I suppose Celestions Vintage wired in parallel), then hopefully your 4x12" is 4 - 8 ohms speakers in a series / parallel configuration which usually it is, then you transformer tap (switch) should be set a 4 ohms running both combo and 4 x12".
Now if you have an odd impedance match that's not compatible with your output transformer tap then you may get a power (wattage drop) thus a volume drop. I'm not sure though. Now someone correct me :?
Do I make sense? Maybe others will chime in what I'm trying to say.