I too had both the MkV and ED for about 8 months last year. Now I just have the V.
To counter Birdy's response.....I agree...The ED is a great amp!
However, the V won hands down for my needs!
Personally, I was not able to achieve a nice balanced sound between all modes of the ED (especially the clean mode compared to the blue and red modes). This was critical to me as I spend at least 50% of my time playing with a nice clean sound. While the ED is capable of nice clean sounds.......I wasn't able to achieve the great clean sound I was after while setting the tone knobs to my liking for the "blue and red" modes. It is a compromise that I was not happy with.
If I were mainly a rhythm player that mostly played mid gain to high gain rhthym sounds (blue and red modes of the ED), and wanted to solo out in either of those two modes from time to time...I would have been in heaven (as long as I had my OCD pedal in front for solos)!
However, I was not able to achieve the clean sound that I was after while still having the shared tone knobs set to my liking for the the mid gain / hi gain (blue and red modes).
Personally, I don't find the MkV to be hard to dial in with any of the 3 channels (and 3 modes offered in each channel). However, I did / do have a problem at times deciding which of the 3 modes offered in each channel to use for a given application.....and yes, each mode of each channel requires special care.
The ED is a great amp.....and is perfect for many people as have mentioned in this forum.
The ED didn't work for me because it wasn't flexible enough for my needs. YMMV
My advise to you is to play the ED prior to purchase to ensure it will fulfill your needs.