An interesting thing to do with humbucker guitars is to pull the bass knob and then turn the lead channel gain way way down. Like 2-3 on the lead drive. With my guitar and my amp (IIC+, not III), I'm talking settings like:
Vol1: 6-7 ("pull bright" is to taste)
Treb: 6-7 pulled
Bass: 2-3 pulled
Mid: 6...you need plenty of mids for this experiment
Master: dial to taste...pull deep (or not) is also to taste...I vote no.
Lead Drive: 2-3...yes, keep it really low for this experiment
Lead Master: to taste...as for "pull bright", I'd probably probably vote yes, though try it both ways
Switch to neck humbucker and start playing some sweet, spongey, soul-full leads. Mmm. Good.
With the bass and gain settings like this, you get a really different quality of saturation out of the lead channel. Sure, the gain knob is really low, but with the bass pulled and with the mids turned up, you've got lots of signal making it through the early part of the pre-amp. As a result (on my guitar at least) you get this really nice touch-sensitive saturation with way less of the fizzy buzz. It's a really cool feeling.
Now I'm not saying that it should become your main lead tone or anything. No, no. It's just a different flavor that's worth tasting. In contrast, a lot of people think that using the pull-Bass is a no-no with the lead channel. I'm just here saying that there is some cool stuff to be found if you turn down the gain so that you give that deep bass some space to work. Sweet lovin' can result.
Chip