I have owned and worked on various Mark II, III, IV and V's over the years. The earlier Mark IIC+, III, IV were setup to run either 6L6 or EL34 (In the Simu-Class amps only!) in the outer sockets but were more biased to run 6CA7/EL-34's. I found later in my Mark V that they did not recommend running EL-34's in the outer sockets due to the iffy quality of EL-34's at the time and so the V was setup to run all 6L6's. I noticed on the outer 6L6 sockets the bias feed resistors were 150k opposed to 220k found on the earlier IIC+, III, IV EL-34 equipped outer sockets, the 150k resistor sets the bias on the 6L6's to run properly, where the 220k would run warmer bias (bigger value 220k, more negative bias, lower value 150k, lower negative bias.) for EL-34/6CA7's. A friend of mine owns a 85' IIC+ that he runs all 6L6's and the outer 6L6's running a bit cold, it had the stock 220k bias feed resistors, so if he had EL-34/6CA7's it would have been in the ball park. I swapped out the 220k's for 150k that I seen in the Mark V all 6L6's, and it works great! I also did a Mesa NO-NO! added a bias trim to bias different manufactured tubes for fine tuning, Mesa prefers us to use their select power tubes which I understand is to make it easier for the user and not to have to bother with bench fees for biasing etc. just buy their tubes plug and play, and for the most part that's great, your sound should be pretty spot on when replacing with their recommended tubes, but in this case if your amp was setup from the factory to run EL-34/6CA7's, and you have 6L6's in the outer sockets, they will not bias properly without the 150k bias feed resistors. The inner pair should be 6L6 unless it was modified to do so, EL-34's may work but the screen grid 470 ohm is too small and will eat the power tubes quicker. They should be 1k screen grids to run EL-34's in the inner pair, though I would not do this, leave the stock 470 ohms there if they have not been changed and run 6L6 there. If you want to run EL-34's effectively you need to make sure the outer pair bias feed resistors are 220k, 150k for 6L6. I hope that makes sense and is helpful