Running the amp with no anode current in the inner pair with a heated cathode could result in cathode poisoning. That may result in a high resistance chemical layer that forms between the cathode tube and the oxide coating. Since you are only using the 60W power mode, that has a potential to happen. Without the tube in the socket, that could lead to other problems too when in a high humidity environment. Not sure the sockets would form any oxidation due to exposure. At least when the amp is active, the heat will dry out that immediate air due to elevated temperatures of the power tubes that are operating. I would make an inquiry to Mesa customer service through their on-line portal and see what their response is on the subject matter. The manual on that subject indicates you should rotate the tubes to extend their service life. No mention of removal except for periodical tube rotation (exchanging the inner and outer tubes). There may be reason why you may not find any types of dummy plugs or caps to cover the sockets. However, if you do opt to make use of something, without the tubes installed, I doubt the 100W setting would pose any issue as that usually is just a disconnect on the cathode circuit to chassis ground to disable the tubes. There will still be high voltage potential on the plate and screen sockets/pins of the inner pair. Something I need to consider myself but with a different amp (Mark VII) as I have been running its 45W mode more than the 90W. As for the JP2C, I much prefer the 100W but I get the point that tubes keep going up in price and may be harder to get when you need them. I sort of got into the habit of getting a stash of replacement tubes so I have them in a pinch. Easier said than done though.