If it's just a loss of volume across all channels WITHOUT static, swishing or microphonics, it's probably power tubes. If one of the aforementioned noises are present, it could be a preamp tube and/or power tubes. If you haven't changed them in a REAL long while, perhaps it's time for a re-tube. I'd change power tubes first as preamp tubes have a much longer service life. Plus which, if you play the amp with any regularity, you WILL need new power tubes eventually. It's also good to keep a spare pair or two on hand. If you still have problems, it might be preamp tubes, or possibly something else.
You can perform a quick check of power tubes which might isolate any weak tube(s). I'd try running the amp in Simul, then switch to Class A. If the volume is restored in Class A, I'd replace the inner pair of tubes. If no volume change when switching to Class A, then I'd swap the inner and outer PAIRS of tubes (with power off!) and re-run the experiment. If volume is restored in Class A, then replace the now-inner pair. If no change, then you might need to replace them all.
Again, it might not be tubes.