Yes, I'm doing something similiar to my Mark IV settings. I'm using a '78 LP custom, and the pickups must be really hot because I always have a really low drive setting on whatever I play, but I still manage to get a light palm mute chunk if I want, and plenty of overdrive. This is what I'm working with right now:
Vol 1: 7.5 pulled
Treb: 8.5 pulled
Bass: 3 pulled
Mid: 7
Master 1: 1-2 pulled
Lead Drive: 3
Lead Master: 7.5 pushed
Presence: 7.5
Graphic EQ: W shape, with 240 and 2200 at the center line, 750 half way to the top line, 80 at the top line, 6600 slightly below the top line.
Try those and tell me what you think. Sounds good at the lower volume I'm playing at right now.
I'm using a Mesa vertical 2x12 with a 12GH30 and a Vintage 30.