Here's a tip: never question yourself for using LESS gain than others. You're probably a stronger player because of it.
I joke, sort of.
The LSC's obvious strengths seem to be in the low-to-mid gain range, but over time I've come around to the opinion that there are amazing lead tones to be had in the higher-gain settings too -- as Octavarius said, they just aren't really tight, "heavy" hi-gain sounds. Different beast really, and not "metallic," but the higher settings offer a really thick, rich overdriven tone with tons of punch and a fair amount of sustain. Think Santana, Cream, and yes, Timmons. It's not about Teh Brutalz (or whatever).
Different boosters can easily tighten up the grind for chunky power chord rhythm, or push it into violin-like singing sustain, which is what a lot of tube amps require to really get that anyway. I really only use one when I'm not feeling very articulate, however... the longer I play, the less I seem to need
Endless Sustain to get the job done, and the more I appreciate the attack and punch that my own hands and a properly pushed amp provide. I like the notes to really
bark.
And even though pedal-generated OD has its nice points, more and more I appreciate the nuanced harmonic complexity and richness that Channel 2 brings all by itself. Far more expressive and cool than a pedal, I think.
Granted, I'm not really a speedster these days... I play jazzy funk and R&B, with some classic rock thrown in once in a while.