Man you don't know how much I feel your pain. My solution has been to pull the presence pot out on R2 and turn it all the way up. then I run the Bass on r2 just below 2, no higher then 2. Then I run the gain, for humbuckers, around 3 to 4 tops. This gets me close to ACDC plexi type sound, which is a lot cleaner then people realize. I think a lot of the tone issues with R2 come from to much bass but also not enough master volume. What I mean is running the amps volume higher to let the tone out. When you push the amp the power tubes start to add that magic tube mojo. The problem with that is the amp is an animal and will blow your head off at home and at gigs. My solution for this is two yellow jackets in the outer tube sockets. Run the amp on class A and run the master volume on 6 to 8 and channel volumes no lower then two, use your guitars volume to take it from there. This is me and I'm an ACDC classic rock guy. Most of the guys here have tried to help me out but a lot of the guys are heavy metal and don't really know where I'm coming from. This is not a slight on you heavy metal guys, it's just different tone agenda. I hope this helps you find your tone. I have only had the MKIV for a couple of months and gigs. The more I learn it, the more I love it. The MKIV can do a lot of things very well. Good luck I still have a headache from struggling with R2. A lot of guys have chimed in about R2 being great and whats my problem etc. I thank you for your thoughts.