My signal signal path is as follows (I'll skip the pedals and start with the Quad pre) Quad pre > BBE 362 > Rocktron Replifex > Rocktron Intellifex (just for reverb and occasionally adding delay) > Mesa Stereo 2:50 > a pair of Framus 1X12 cabs w/Celestions. If I use the cabinet sim in the Replifex, I run a pair of Yamaha PA speakers instead. Everything from the Quad to speakers runs in stereo. I read a post about not having a powerful or present sound and some one thinking it was the Quad or 50/50 causing the problem. Definately not the Quad unless something is wrong with it, not sure about the 50/50 but my 2:50's presence controls don't effect the sound until about at 2 o'clock and i usually run them at about 4 or 5 o'clock. The BBE is the key to a clear, powerful tone for me, clean or with distortion. Another factor is the use of the parametric eq in the Replifex, makes a huge difference and really brings out a lot of different tones. If I was having difficulty finding a good tone with any good guitar equipment, i would immediately plug in a BBE Sonic Maximizer and a parametric eq.