Shouldn't be a problem, though I would protect the cab, as others have pointed out.
Back in the day, it was common to do this with the old horizontal 212 Bassman and Bandmaster cabs. And then of course, CBS went to the oversize cabs. I think those were for looks more than sound. Fender need bigger cabs to compete with the looks of the Vox Beatle and Marshall stacks that were taking over rock music.
I like to use a Mark III combo or a Mark IV combo on top of a Theile 112 cab. This is a small footprint, it produces gobs of bass, and projects really well--and gets the control panel of the Mark IV up where these old eyes can see them! LOL!
The 212 and 412 Halfback cabs are great too, because they have small footprints. The 212 is bigger than many 212s, but that bottom part is Theile-ported and those cabs will out-perform most 412s. The 412 Halfback is something like, one inch larger than a Twin Reverb cab.
I think that if I were to order a LSC or LSS, it would be the 112 combo, with a 112 extention. I like using my Maverick 212 with a 212 horizontal Recto. That's a gorgeous combination--the Recto adds a lot of bottom end thump, though it's too big for many of the small stages. The 112 plus an extension seems to be what works the best, and is the most practical and portable, for me.
Bill