Mesa uses a fixed bias and recommends Mesa tubes because they choose them to fall into that range.
A general rule of thumb is that class AB amplifiers are usually operated at no more than 70% of the maximum plate dissipation of the tube (to account for the higher dissipation that occurs under signal conditions), while true class A amplifiers generally run right at the maximum plate dissipation (the dissipation at full power is lower than the dissipation at idle in a true class A amplifier).
For example, the aforementioned EL34 tube has a plate dissipation of 25W, so at 400V class AB operation, it should be biased no higher than (0.7 * 25/400) = 44mA. At 500V class AB operation, it should be biased no higher than (0.7 * 25/500) = 35mA.
This doesn't mean you should automatically bias all tubes to 70% of max dissipation!
They can be biased at any lower current if desired, and many people prefer a point of around 50% to 60% of the max plate dissipation, which contributes to longer tube life.
In true class A operation at 250V, it should be biased no higher than (25W/250V) = 100mA. Note that a class A amplifier does not necessarily have to be run at the maximum ratings. You could design a true class A amplifier at lower plate voltages and higher currents, but there is a limit to how high the plate voltage can be without exceeding dissipation ratings, or having to go to class AB. There is also a limit at how high the plate or cathode current can be for a particular tube. A class B amplifier should be biased right at cutoff, or perhaps a few mA standing current, to minimize crossover distortion. Class B amplifiers usually have extremely high plate voltages in order to maximize the output power, so they must be biased right at cutoff to prevent over-dissipation at full power. If in doubt about the actual operating conditions of the circuit, call the manufacturer or refer servicing to a qualified amp technician .