I also used to use an MXR 10 band EQ in the loop of my other amps. But on the Mark V, the sliders on the dirt channels and the Preset Depth knob on the clean channel get me all the EQ I need.
EQ is the secret to unlocking the tonal power of the Mark V (it's true of all amps, really, but MUCH MORE SO for the Mark V). Watching some good videos on settings is a great start, but afterwards, just trial and error will get you where you want to be.
But please avoid the HUGE mistakes I made the first time I played the Mark V - don't forget that small changes on the channel EQ knobs can make BIG tonal changes. I was a Marshall kinda guy for 30 years. The first time I played the Mark V, I tried a setting, didn't like it, then made huge changes to the EQ, didn't like it, etc. After about a minute of this, I was convinced the amp held nothing for me.
It was more than 6 months later before I tried another Mark V, but this time, I was more educated on how to use the channel EQs. Also, on how to use them in connection with the Global EQ. It made all the difference in the world.