I just re-tubed my .50 Caliber + and with at the recommendation of the dude's at my local Guitar Store (Long & Mcquade) and here's what I got:
2 X 6L6 Groove Tubes (POWER SECTION)
4 X Tung Sol 12AX7 (PRE AMP SECTION)
1 X Electro Harmonix (PRE AMP - in V2)
The Tung Sol's are were recommended to me as "fuller/more defined or detailed with in terms of clarity"
And they are! I am happy with them, the Groove Tubes are good as well, much better than the Mesa 420 STR's that were in there, BUT, the Mesa's were old so I didn't have a fair shot at jugging the two...but, If I were to buy another set I would try the Mesa Boogie STR 440's. I have heard from Mike B at Mesa and countless others that the Mesa STR 440's are the way to go for Power Tubes!
I play strictly METAL: Metallica, Pantera, Slayer, Megadeth, Testament type stuff....My tone is closest to Hetfield's 89 Live tone era....