Beyond just EL34 and 6L6 there are a lot of possibilities.
Anyhow, for my DR Roadster, be careful about bias (I don't understand bias properly so I just order matched sets/quads from eurotubest) but I am using combinations of 6V6, 6L6, EL34, KT77 and all tubes have different tone. My favorite (current) combination is an integrated quad of KT77/6V6.
The sound of these tubes? I find EL34s nice and clear sounding but top end is a bit grainy, KT77s smooth that out. I find 6L6s have great thick bottom end thump but sometimes a bit muddy, 6V6s have a nice round bottom end with not as much thump as 6L6s, but lower mids seem more articulate and have good harmonic content. So that is the combination I prefer at the moment. My tastes change at a moment's notice though!