I have two strats - one is a 1989 strat plus with the Lace Sensors and the other is a 2001 American Deluxe with the nioseless pickups.
I use a DC-3 and an F-50. The Lace picups sound great through both amps and sound very 50's to my ears. The nioseless pickups are a bit different. I think they do a very authentic 60's style strat sound, and can cop a very good Knopfler and Gilmour clean type of sound. But they are not high output pickups by any stretch of the imagination, and don't seem to be as well defined when the amp is in overdrive. I have had to adjust them to get them so that they sound good through both amps.
They seem to do better with the DC-3 than with the F-50. I found that I had to lower the height of the neck pickup quite a lot in order for it not to sound too muddy, but I keep the middle p-up at standard height. The bridge pickup I've had to raise as high as I possibly can without string interference. I think they are good pickups in general though. I guess you have some sort of a trade off when you eliminate the hum/noise, and they do that very well. Some folks like them, but I know a few players who really don't care for them. The one thing I do notice is that they sound WAY better when you have new strings on. As soon as the strings lose that "just put on" lustre, the pickups reflect that immediately.
I'm also considering swapping them out, but I'm not sold on any replacements yet. I don't want a humbucker-style pickup, but I don't want to deal with 60-cycle hum. It seems like an acceptable trade-off - at least to me.