I run my gain on 5-6, treble on seven, bass on two, (pulled) middle on 7, master on three (pulled) no presence.
I like a fat clean rhythm sound and to compensate for all this bottom end I wind down the first 2 eq faders down and set the eq for lead mode. I like my lead sound warm so I also wind down the top 2 faders as well; this gives me an inverted V. I don't boost the midrange, it's just set flat.
This set up works well if you're not looking for a metal or hard rock sound and want a big warm rhythm and lead sound out of a combo.
It's more of a blues or Santana like sound but without the high gain fizz on the top. If I want a little more gain and middish tone I combine R1 and R2.