Chasing tone can be an expensive habit.
You have to first define your need. I came from the 80's school of hair metal, and that is the tone in my head and shaped a lot of my technique...but.... I play in one of the top bands in my area, and we play classic rock, country, a smidgen of blues, and some pop rock originals. We do not play any 80's hair metal. I've kindof outgrown that now, anyway.
So, I need Marshall crunch and 'sizzlin' Fender (pushed) cleans at a reasonable stage volume. This basically puts me into a 40W power amp with 96dB speakers, or a 20W amp with upwards of 99 dB speakers. The tube amps that fit that bill are the Mesa Heartbreaker, and the Fender Supersonic 22. I have the Heartbreaker, my wingmate plays the Fender. The Mark style tones are only interesting to me for mid-gain modern country lead tones. Otherwise, I find the Mark series to be limiting to me. I tried a MkV in the store, and while I know I have enough skill to pick the right tubes for it, it never really did it for me out of the box. I liked the Mesa Express better. But still, I need Marshally-crunch, or I'm just not gonna be happy. I decided I don't care for 6L6's, I love EL34's that are on the edge of breaking up, and get along fine with 6v6's. Power tubes and the class of power amp has a incredibly huge impact on tone and feel.
The second thing i discovered after playing open back cabs all my life, is that my guitar playing improved overnight when I went to a tight and punchy 2x12 closed back cab. The tight and punchiness seemed to reduce the "latency" of the sound filling the space around me, and suddenly my left and right hand worked together more naturally. I have a harder edge to my playing, whether country or rock, and this type of cab brought it together for me. Once in a while, I'll plug into my open back cabs - and bask in the fullness of my living room tone, but ultimately, I enjoy them for 15 minutes or so, but then I'm back to the closed back for a month of practice and gigging. On the other hand, my wingmate is a more laid back more melodic kind of player and he prefers open backs. When I finally made the move to close backs this year, he said my tone fits my style way better now. Our vastly different approaches to guitar keeps our audience's attention.
Anyway - in summary, you need to find out what is the tone in your head relative to your objectives is - and move in that direction. The only way to get there is to try a lot of different amps and cabs and discover the ones that rock your world for what music you want/need to play. Maybe a pattern will develop in the amp voicing, speaker cab preference, and speaker selection. Its hard to say no to a Marshall voiced amp if you're into rock, and same goes for Fender and country, although I have heard very nice country riffs played through clean Marshalls and rock played through on the edge Fenders (eg. Stones, Mellencamp, etc.)
If you're into more modern tones, cleans, blues hard rock, maybe the rectifier derivatives like the Tremoverb would suit you best. If you want a blend of classic tones and recto tones, don't dismiss the much maligned Nomad, just make sure you find the right cab for it...probably a rectifier cab.
If you can't get an awesome sounding total rig for under $2k, meaning everything - guitar, cord, amp, cabinet - you're not shopping right. Most everything I own is via ebay or online classifieds in like new condition for half price of new. I think one properly configured amp is all a person needs. You just gotta pick the right one, preferably with half power switches or "amplifier class" switches! Most Mesa's over the past 15 years give you flexibility.