I wouldn't do it.
With an 8-ohm load and a 4-ohm load, your overall impedance is going to be 2.333 ohm, which is almost half of the expected load. Mesa gear can probably handle it, but it's not the greatest idea anyway.
Also, the 4-ohm cab will be getting twice the power of the 8-ohm cab, due to the fact that lower impedances dissipate more power.
I'd say pick one or the other, or put some new speakers in the 4-ohm cab to bring it up to 8-ohm.