If you use two 8-ohm speakers wired in series the 2X12 cabinet will be 16-ohms.
This is how my Avatar 2X12's are. One cab has two 8-ohm Hellatone 60's wired in series for 16-ohms, the other has two 8-ohm Mesa Black Shadow C90's wired in series for 16-ohms also. When used together in parallel the total load is 8-ohms. This allows me to also add my 8-ohm Recto 4X12 in parallel for all three cabinets at a 4-ohm total load.
I found this to be the most versatile for me. If I want to run one 16-ohm 2X12, I plug straight into the 16-ohm jack on the amp. If I want to add the second 16-ohm 2X12 I daisy chain them (parallel) to 8-ohms and plug into the 8-ohm jack on the amp. If I want to run the 8-ohm Recto cab and one 16-ohm 2X12 cab I plug the 8-ohm Recto into the 4-ohm jack on the amp and the 16-ohm 2X12 into the 8-ohm jack. To run all three cabs I plug the 8-ohm Recto cab into the 4-ohm jack on the amp, then daisy chain the two 16-ohm 2X12's to 8-ohm and plug that into the other 4-ohm jack on the amp.
These are all CORRECT impedence matches that were confirmed by Mesa.
The poster running the 8-ohm and 4-ohm cab setup is pushing a 2.6-ohm load, IMO stressing the output tranny. Mesa's trannys are very strong and may run fine for years like that, but I personally would not run lower than a 4-ohms total speaker load, which is the lowest output transformer tap per the schematic.
Dom