The 22 is very responsive to whatever guitar you are playing. I have had great luck with Fender guitars after changing out speakers, getting killer cleans and especially good jazz/blues tone-The amp also is quite sensitive to tone control changes, The treble control especially acts as a boost when above '7'-I generally start at 5 on each setting and move accordingly. Pull out the mids a bit. I still am not sure I like the gain channel that much-too much honk-really needs to be cranked for best tone, whereas the cleans sound really good at low volume.