take a look at all your current settings and try the exact opposite.
automatically switching to neck humbucker for fat solo tones? go for your bridge pickup instead (even better if it's split/single-coil! If fat solo tones are where it's at, why do all these guys play Teles...?)
Always "scooping" your rhythm tone? turn up the mid instead. turn the gain down; turn up the master volume, or vice versa.
Borrow a friend's amp, doesn't matter what it is, and start playing it with whatever settings he had when you picked it up.
if you're a metalhead, turn on your local country radio station and try to cop one lick, note for note, out of every song...!