I have been gigging/touring with the ED as my main amp for about a year and a half or so. Yes the amp is a very simple setup, but when you play music that is not necessarily the ED's forte it takes a lot of work/time to figure out how to find that tone buried within. It was frustrating at first to the point I nearly sold it on multiple occasions, but thankfully I have hung on to it and I'm finally figuring out how to effectively use it for my needs.
First let me state that I play in a band that could be compared to Thrice (Vheissu era) and Emery. At times we get as aggressive as August Burns Red or Memphis May Fire. Obviously the Electra Dyne is made more for vintage rock tones so it may not be the obvious choice, but the amp's clarity, simplicity and articulate nature are what drew me to it. I play a mixture of rhythm and lead, but I tend to do more leads than our other guitar player who uses a Marshall JVM 410H. I'm not crazy about the JVM personally... It's pretty thin sounding in comparison to the ED, but the two blend nicely. The EQing process took a while because I trusted my eyes over my ears for a long time, it was hard to get over the fact the EQ looked weird and focus on the sound. I found it harsh and I always thought it came from the treble and presence so I always dialed them back but was never happy with the results. Over time I realized the ED is a very "middy" head, I finally drastically turned the mids down to the 8-9 range and the harshness began to vanish, even with V30s. Decreasing the mids created a similar effect of moving the middle fader down on the Mark V or similar configurations, but I still didn't lose the cut in the mix, thankfully. I keep the presence at noon, bass around 11-12, mids 8-9, treble 1-2, volume 2-3. Using logic I never touched the 45 watt option, but after putting Valve Art KT66's in the power section I found that I liked pushing the power section (the opposite of what I thought with EL34s and 6L6s), they make the tone sound more powerful to my ears and less fizz on the high end. It doesn't get buzzy at higher volumes and I find myself liking to push to power section where I used to hate to push the power section. While all this drastically helped me connect with this amp more the one thing that literally kept me from selling this amp was ironically... the EMG 85 pickup in the bridge position. I've never considered myself an active pickup guy, ive always used duncans (JB-59, custom custom, etc.) and Dimarzios (Drop Sonic, X2N, D Activator). I had an ESP EC-1000 with an 81 in the bridge for a while, but that was a few years. I was working on my tone and I decided to try the other guitarist in my band's Michael Kelly Patriot Supreme with an 85 in the bridge. I hate EMGs with amps like rectifiers due to fact the head is naturally scooped and doesn't need high output pickups. The modern tonality of the 85 balances out amazingly well with the ED's vintage voice. (with this pickup only. Yes, I tried blackouts, the 81 and even the EMG X-series, none of them sounded as good.)
My setup currently is:
Michael Kelly Vex Deluxe (w/ D Activators) or Patriot Black (EMGs) -> Line 6 M9 (I'm thinking about switching to an M13 and run the 4 cord method) -> Electra Dyne -> Road King 2x12 (C90/V30) and Rectifier cab 4X12 (G12H 70th Anniversary, Greenback, 2 V30s)
So with the 85 I'm pretty happy for now, I still want to play with preamplifier tubes, but my secret to success for thick high gain with the Dyne is boost to volume in the power section (KT66 tubes) while in 45 watts, keep the preamp gain on the conservative side and rely on high output pickups and a heavier right hand technique.
As far as mode switching, I pick lighter with chorus/reverb/subtle delay on the clean mode to avoid break up, vintage low for more conservative rhythm sections, vintage high for aggressive rhythm and a boost with reverb/delay for leads. I want to get a mini amp gizmo with an M13 to avoid any button dancing on stage.
After all is said and done, the ED had to grow on me, but I'm finally happy with it. I still want to try a RA-100 for kicks but as for now the ED is my favorite amp on the market and can honestly hold it's own against any amp IMO.