Concerning preamp tubes, are there any cathode follower circuits to be aware of? I do know the Mark IVb and Mark V did not have any, not sure about the Mark III as I never used other 12AX7A in that amp other than the Chinese branded mesa tubes. I have noticed my JP-2C seems much brighter than it did a few days ago but I have been exploring different settings and such. I may try a different PI tube or other preamp tubes if needed but so far amp still sound great. I do not feel like spending $600 for a quad of the STR415 tubes at the moment.
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First time for discovery of guitar cable being culprit. I was using my Mogami Platinum plus cable, that will definitely bring out the brightness. I switched back to the cable I was using which was another Mogami but not the heavy cable and amp sounded much better as it did. The platinum cable works great with the Roadster or RA100 but the other cables suffice just as well. I did not expect it to be that much of a tone change but it is... If you find your JP-2C too bright or brittle sounding, try a different guitar cable. I actually prefer just the run of the mill standard cable. The Mogami platinum was a bit too expensive for me to want to get another. Gold standard or other will suffice plus they are less cost. One feature on the platinum cable I like is the neutrik silent plug switch on the instrument end. I have seen that on other brands of guitar cables as well. Back to my original thought, no need to swap tubes out at the moment.