Let's see, I'm very familiar with a variety of 2 x 12's but not with the Stiletto. Haven't had a small gig yet to bring one of mine to, its been all 4 x 12 thus far. I'd look at the VHT 2 x 12's. I'd also check out the THD 2 x 12 looks interesting and is NOT a V30 design. Andy specifically dislikes the V30 sound so thats a good thing.
Haven't swapped the tubes yet, don't think its necessary for sound reasons, the stock tubes sound good and aren't microphonic at all. What are you looking to change about the sound or fix?
I don't own a strat but I have played the amp with single coil guitars, sounds great especially for jimi hendrix style twang. I turned on a flanger and went to the single coils. My bass player turned his head around it was so spot on. I was using the crunch channel on with the gain at about 3 oclock but with the volume dialed down, all neck pup. sweet, sweet tone.
-P