I've just started experimenting with this. It definitely sounds way different than a regular set up. I've been playing with a stereo / partially wet-dry set up.
I'm using an F-50 combo and the main amp (left side), and a DC-3 combo as the right. Here's the signal chain:
Up front: gtr>q-tron>compressor>phase 90>F-50 input.
Loop: F-50 effects send>rack tuner>delay pedal>stereo chorus pedal>left output to rack reverb>F-50 effects return.
The right side of the stereo chorus is then sent to the DC-3 effects return.
With this set up, there's true stereo chorus happening, but the reverb is only going to the left side. When the chorus pedal is engaged it makes a HUGE sounding stereo spread. When the chorus is not engaged, it doesn't sound as big spatially, but it's definitely an interesting sound with the reverb only coming out of one side. The trick is in balancing the apparent volume on both sides. Tonally they are different for me, so it's been tricky getting the volumes set correctly.
Part of what I like about this set up is that the left side is using the 6L6s in the F-50 and the right side is using the EL84s from the DC-3. Different sounding power amps both driven by the same F-50 preamp. It's cool.
Obviously, if your miking up your rig, ideally you would want both cabs miked up - assuming the sound guy is also running a stereo system. In my experience most of these guys have stereo boards, but run them in mono.
I'm going to try this at a gig this weekend. It's definitely a pain in the ass setting it all up, but in reality the only "extra" thing I'm bringing is the DC-3, and I usually bring that as a back-up anyway. It's a cabling nightmare at the end of the night though, I'm sure.