Hello Gazza,
If you want to operate both channels of the 2:90 you will require 2 cabinets.. or a stereo cabinet with a switch allowing you to drive each speaker with a separate channel...
(Mesa has this stereo option in the Rectifier 4 x 12 or Road King 2 x 12 cabs)
Here's some options...
OPTION 1 : [2] 2 x 12 Rectifier Cabs
I would choose the Rectifier 2 x 12 but [2] of those are really expensive and heavy
______________
OPTION 2 : [1] 2 x 12 Rectifier Cab
If you want to use a single 2 x 12 you can connect the 2 x 12 to the 8 Ohm output of Channel A and connect a load on the 2:90 Channel B.
______________
OPTION 3 : [1] 2 x 12 Road King Cab
Operate in Stereo from both channels of the 2:90
______________
OPTION 4 : [2] 1 x 12 Rectifier Cabs
To get more compact, with 2-speakers, you could do what John Petrucci is now doing with [2] 1 x 12 Closed back Rectifier cabinets.
These cabinets a 60 Watts RMS, so, you could also use just one channel of the 2:90 by connecting both 1 x 12 rectifier cabinets to the 4 Ohm outputs of the 2:90 Channel A and connecting a load on the 2:90 Channel B.
This will allow you to turn up Channel A as you will have 120 Watt RMS capability.
______________
Now you might need more stage volume if you are not using In-Ear-Monitors or if you are not micing your Amp in the P.A.... The best way to hear yourself better is to get the speakers up...and/ or do a side-wash if possible. (sound-guys will love you for this)
I mounted 2 speaker flanges to the bottom of my 1 x 12 cabinets to allow small stands to lift the speakers. I also always side-wash my speakers as I need to be able to access controlled feedback as necessary.
I know 1 x 12 cabs don't look as sexy as 4 x 12 cabs, but, its much easier to transport and move around small cabs and two small speaker stands.
We usually play with other bands, so, I set-up my two side-wash cabs and I let them set-up their stacks behind me so it looks like I'm running through their speakers
You can see those 1 x 12 cabs on stands at Stage Right in the below pic.
PS: I am driving those cabs with 2 channels of a Mesa 20:20 Power Amp with plenty of headroom for solos and plenty of stage volume. There is an added benefit that the rest of the band can hear me and I dont have to show my butt to the audience when I need some controlled feedback.
I hope this helps
seeya
Joe