Well i work like this my friend
Ch 1 Tweed
Ch2 it is actually my main, i use mark 1 mode no Eq, its bigger in any way you can imagine it fits well in the mix for live and rehearsal, depends on what guitar am using for me, let me explain, when i use telecaster, and SG i use this as the main and almost the only overdrive sound, it cleans very well with the volume pot, and gives a lot of body to this particular guitars, i like Fat sound, creamy leads, for les paul and stratocaster i use this channel only for leads, because of the pickups i use in that guitars, for the strat the invader which is fat as hell, and for the les paul the full shred which actually its so fat too, keep in mind that i for the style of music i play its my main channel for dirty jobs.
Ch3 i use this channel as the backup channel or the "articulate riffs", i use mark IIC with EQ, for some riffs when i need to articulate, mostly riffs played in the fat strings, but with the same logic on which guitar im using, also i use this channel in triode, and i use it for some leads but not all, something i found with this amp is that depends so much what guitar im using , i played my strat for years and use that strat with the mark V for a year and a half, then when i bought the other guitars i started to experiment again with sound live and for what works better, its a mess if i try to explain to you all i do, because i know in my head what guitar for what song, also what channel for what guitar, and all that for what part of a song i do, its a lot of info,
but if theres anything i can say is you ll discover to much for this amp and you will never stop the learning, its a fenomenal amplifier , i believe because all the threads i read, that im one of the fews that uses this amp in a very different way, most people use petrucci settings, or the classic EQ, and theres nothing wrong with it, but the best advice is search for the sound you want in your head, i find to hard to believe that this amp cant do it , unless you love digital sound jaja
hope it helps.