I am very much in the Santana school of tone and I live on these settings on the MkIIc+: V1 on 7 pulled, Treble 6 1/4 pulled, Bass 2-3 pulled, Mid 8 pulled, Master 2-3, Lead drive 7, Lead Master 2-3 pulled, presence on 1. Almost always with a PRS Santana III guitar. I ride the volume knob heavily, using 8-10 for sustaining notes mainly, treble knob usually rolled off a little too. My Mark III back up amp is close to these settings with sometimes a little more volume on the pre-amp but this should get you pretty close.
If you'd like a sound sample of how I use it here it is: https://www.youtube.com/watch?v=tRY3X_vqLoc