Currently, I've been using my TC50 for clean tones only. I also currently use 6V6 power tubes. My clean tone is absolutely amazing, especially through my EVM 12L single 12" cab. I only use the clean mode. It is exactly as it says: Clean. Massive headroom, shimmering, and FULL. If I want a touch of grit, I flip the switch to Drive. But, that honestly never happens with the current band I am in. I do have to dial the highs down a touch, especially for using the Cab Clone, but it definitely rivals my Mark V and RK1 for cleans. The V and RK have more diversity in their clean channels, but my TC gives me exactly what I need. For this band, I primarily use a Strat or Tele with single coils. One Tele has 2 tapped humbuckers that I occasionally use, and it's just as beautiful with that guitar, too.
I have never tried to get a Clapton tone out of any amp I have, but when it comes to Mesa, you can pretty much get any tone you want with any of their amps that have multiple modes per channel. It's all in the tweaking of the knobs and time. There are no shortcuts. The more dials there are, the more time it will take. The RK is almost a life-long quest for tone! My Electra Dyne was easier, with only 6 knobs and 3 modes. But, many have struggled with that amp, too, because of the shared EQ. I guess I just got lucky.
On the TC, believe it or not, all my knobs are set within 10:00 to 2:00; not a ton of variance. Most of my pickups are Seymour Duncan passive pups. I have one EMG packed Strat, and the available tones there are almost limitless due to the SP1 pot. I also use an Emerson blender pot on one Strat that lets me blend in either the neck pickup or bridge pickup in all but the center selector switch setting. My Strat will sound like a Tele if I want it to.