This is common in amps with a "clean" and "high gain" channels.The overdrive channel develops a lot more gain,or amplification,if you will.All tubes have some degree of microphonics and noise,when you use the overdrive or high gain channel these noises are amplified more than in the clean channel,some tube suppliers sell tubes that are specially selected for low noise or microphonics to be used in high gain amps for just this reason.In some cases components,like a plate load resistor,become noisy,in that case tube changes wont help.