I have EMGs zakk wylde set in my ibanez. Basically, if you like heavy metal riffs and you detune (my ibanez is dropped down 2 steps) they are great but they sound pretty awful for leads, completely toneless fuzz. Just listen to Kirk Hammet or Zakk Wylde to see what i mean. Trust me Lukather is the complete exception regarding getting good tone out of these pickups. Out of interest i played a mates Musicman Luke through my amp and the sound was pretty awful compared to my Petrucci model Musicman with Dimarzio's in. Anyhow, other players that use them are all pretty much from a heavy metal/Shred background, you know, Rusty Cooley, Jeff Loomis etc etc and those guys all play a 7 string so you know, great for getting the low notes to cut through but too fuzzy and piercing for the higher stuff.
It depends what guitar players you like but personally id prefer a set of passive Dimarzio's or Duncans any day of the week. If you looking for a really hot sound your probably best using moderate to high output pickups and driving you amp harder like Slash does...however these duncan active pickups might be something to hang around and try.....