I use it in my FX Loop...
EB Musicman Silhouette -> Peterson Tuner -> Mark V Input -> Mark V Send -> Dunlop Wah -> MXR Carbon Copy -> Boss Chorus Ensemble -> Mark V return.
Depending on the gig and the overall volume I am playing at...I go between the following settings. Works for all channels IMHO.
10:30
10:30
12:00
for high volume
or
12:00
12:00
12:00
for low volume.