Are you referring to the frequency sliders or the volume and gain sliders? VERY subjective, as far as the freq settings, and what type sound you are trying to get, i.e, boosted mids, scooped mids, or whatever. Also, the same settings are gonna work differently with different amps. The owner's manual for the MXR comes with a few sample settings which are a decent enough starting place if you're not experienced in dialing in an eq. My best advise is start with the sample settings and tweak from there until you find what you're looking for.