Hi Jeff,
I adore my live rig with my F-50 - I use it with a G-Major thus:
I have the loop at maximum Mix, and I have the G-Major switched IN all the time - however I could switch the G-Major into Bypass mode if needed.
I use the Preset Boost feature of the G-Major to get a Solo boost whenever I wish. I have the G-Major automatically switching to the desired amp channel too (Rhythm, Lead and Contour), so I can get a solo boost for any of my combined amp channel and FX patches.
I highly recommend such a set up. There's a lot more detail about my set up over in the HCAF
G-Major MIDI Tips thread. Furthermore, you can see me using that Solo boost feature in the video clips in my
P&W Gig thread.
Other approaches you might consider include, building a footswitchable attenuator box for the FX loop. Stomping on the footswitch would go between No Attenuation (i.e. Solo boosted) to Attenuated (i.e. normal volume). There's more on such projects over on HCAF in the
F-series Lounge - hal9000 has built such a box.
Another approach you might consider is to get a Looper (MIDI controlled perhaps) to enable/disable any effects that you have in the FX loop. Check out products like the GRX4 from http://www.axess-electronics.com/
Don't hesitate to ask if you have any questions. 8)
Big smiles,
Andy.