"STR" was an acronym that meant the particular tube was the product of a special request...I've heard that it meant "Special Tube Request", but I think "Special Technical Requirement" was probably more accurate.
The original "STR" as applied to guitar amp tubes was the Sylvania STR 387, which was a 6L6GC designed to handle the very high voltages in the '70s Fender amps (550V+), and be highly reliable when used in combos, upside-down.
By 1980 or so, though, companies weren't making bunches of different versions of the same tube. The 6L6GC, 7581A, and 7027A were all basically the same tube with some ratings difference and (in the case of the 7027) different pinout. It was cheaper to make one set of guts that met the highest requirements, then label it accordingly for the various packages. So, any Philips/Sylvania 6L6GC or 7581A made from the late '70s on is identical, and they're the same tubes that the Mark series and associated products (295, 395) would have shipped with.