simply put as - preamp = the thing you plug your guitar into to get your tone, then preamp into the poweramp. the poweramp serves one purpose - to amplify the preamp level because it's a really low signal and can't be heard ( think of it as a "master volume " on the amp ) and the preamp is are the EQ and gain settings ) also note that, the poweramp has a distinct tone as well.. so that's why people prefer different poweramps. all these factors contribute to tone. now to answer your question about the name 20/20 , and 50/50 these are named because these mesa poweramps are in stereo.. meaning two distinct channels with distinct volume knobs. Most preamps are in stereo ...so you just send one channel to a cab and the other to another cab.. this is usefull for nice stereo effect processors.. hope that helps,