Yeah, the longer they glow the harder they are on the components. It's not bad enought to pop the fuse, but every second it red plates you loose a weeks worth of tube life. In many cases the heater filament wire lays against another internal component and the tube freaks out.
Both EL-34's need to be changed. For the screen grids to blow, it's usually a violent tube failure. One that just red plates too fast to catch before the HT fuse can blow. the tube blows and takes the screen grid with it, then the fuse pops. Out of all of the MK series amps I have seen, oddly the only blown screen grid resistors were on the inner two sockets.