We play mostly classic rock in this band. On my own I play everything from Adult Contemporary (Windham Hill type stuff) to Metal. I have not found this to be a very good metal amp, but I think it has the best clean sound of any amp I've ever played (even better than my '65 Deluxe Reverb), and Vintage LO is good for any kind of blues or rock. I usually switch to HI for leads, and have a clean volume boost in the loop as well (was using a GE-7, just got a micro amp). For metal I have an F50 and a Triaxis.
I generally play 7 string guitars with 0.010-0.059 strings. The pickups I am using are Dimarzio: Evo-7 and Blaze-7.
I prefer the tightness of the 90W setting, but usually play 45W because 90W is too loud. For sure the clean sounds better at 90W (I wish I could set the amp for 90W in clean mode and 45W in HI/LO).
Master 9:30
Presence 12:00
Bass 11:30
Mid 11:00
Treble 1:30
Volume 2:00 - 2:30
Reverb ON, 9:00
Clean Level BYPASS
Gain Trim CLEAN (I love this feature, keeps clean from getting pushed)
This gets me decent tone and good level match on all modes. Definitely good enough for live. At home I tweek the settings for each mode, and tend to use the videos on the mesa site as starting points.
I only got this as a practice amp because my triaxis rack is a huge pain to move. But I wound up using the Dyne live because it sounds SO NICE. For more contemporary rock I would probably use the Triaxis, but I haven't decided yet. I could always go Dyne + Metal Zone...