I believe so. I have the 2101 and it can. As long as you have an effects loop on your amp and the digitech, your set. Just line in to your amp, out its effects loop send, go into the digitech effects return (thus bypassing its preamp) and then send the output of the digitech into the effects return on your amp.
My unit has a setting for internal control of the effect loop on every channel, with three settings, bypass, sum, and no sum. If yours is set up the same way you will want to select No Sum.
Otherwise, if its set to bypass you will get no signal and if its set to sum it will combine the effects loop signal coming from your amp with the input signal on the front end of your processor (which is none existent with this set up.)
Make sense?