I know I can't answer your question but I guess it does depend upon the combination of cabinets you choose; for the 1 x 12” arrangement you could go for two open cabs, open & thiele (closed & ported) or two thiele cabs. Personally I like the combination of an open back cabinet along with the thiele cabinet; in which case you can go either way. I believe the closed ported thiele cabinet gives you a tighter bottom end - but I will leave that up to the guys here who have greater knowledge than me to confirm / explain.
Another aspect to look at is who carries your gear around? A fully loaded combo, especially with an EV, weighs a lot (not sure of the exact figure, but I know it nearly kills me) so a head and two cabs may be a more agreeable route to take. Just a thought
Ian