On my strat w/ singles I like the Fat mode, treble down a bit, mids up a bit, bass to taste, presence about halfway. I like to crank the gain sometimes or just set it above breakup. I've also had good results with the Brit setting with the treble at 10 oclock, mids at 10, bass to taste, gain to just breaking up. This channel sounds better in the mix because it cuts but the Fat sounds better by itself. The presence knob does help bring out some sparkle. I don't even use the regular Clean setting because its too thin for my tastes. Fat/brit/tweed all have easily obtainable cleans though, as long as you're tasteful with the treble and gain.