Info below but:
Prevention is the best medicine for this problem. If you feel the need to keep changing your tubes,
and you refuse to gently hold the tube clamps and rotate them very slightly as you pull them, then
leave them alone. Most tube guide pins break for two reasons in my experience.
(1) They have been in and out so many times it weakens them.
(2) The person removing the tube pulls them "straight" out, yet at an angle and pop.
To your question on the tube safety.
Make sure your tube clamps are tight esp on that tube. The guide pin, also adds some stability,
thus I would make sure all your tube clamps are tight,within reason, yet a tube without the guide pin
sometimes may move a bit more during transit. After a few moves if it stays put you should be fine.
There are many ways to add to this conversation, Yet if you find the guide pin, use the white dot theory,
you won't need to let this get very involved. Yet if it were my quad of EL34, metal base mullards, I would
still do the same white out dot. Perhaps order some of the slip on tube keys in case my son decided
he wanted to play at a friends house without asking.
A quick note to add to my white out method. I also have a method I use to get the guide pins out when they
are stuck in the sockets. Some sockets they will fall through, but most recent mesa's they just are hard to reach,
thus my eraser side of the pencil, it really does not matter but I use that side, take some strong tape and make a small
loop, attach it to the part of the pencil that will give you the best angle and press down, Presto I have never NOT been
able to retrieve one, unless it is the socket with a large enough center hole, or the tube guide broke so far from the tube base that less than 1/8th of an inch is in there. I would then find something smaller and still use double sided tape or make a loop of tape as I suggested.
Some older tube amps I have to get into the chassis where they fell.
/cheers