Any 6L6 will "run" in any amp designed for a 6L6,but it must be biased properly.Mesa uses a fixed bias supply,just like many other amps do.Mesa buys huge lots of tubes and checks the current draw and then grades them to match a particular performance in their amps.Makes it easier for your average guitar player to change his tubes,but doesnt neccessarily give you the absolute best performance from the tubes.Tubes must also be "matched",which means a pair of tubes or a quad will all draw the same current in a given amp.Just because 2 tubes are labeled 6L6 doesnt mean they will have the same current draw.