I use the MXR 10 band in the loop. I also use a Danelectro Fish n' Chips in front after my OD pedals. With the one in front, it helps greatly because most OD pedals only have a tone control and I feel that is not enough. The pedals tone control just doesn't allow a boost or cut in bass/treble. They usually sound somewhat 'flat' and lifeless and some pedals just sound 'bland'. Add an EQ in front and you're in business. Even with the MI Audio Blues Pro and Crunch Box pedals, as well as the Tube Zone pedal, the EQ enganged makes a huge difference. And these pedals are excellent.
The MXR in the loop I had setup for 6L6 use but I have since swapped to Winged C EL34's. Much better amp, I feel, as the slightly more compressed nature of the EL34's suit me better. The EQ curve had to change. The loss of bass I bring back in via the EQ and the amps bass/mid control. Treble was adjusted accordingly, too. Of course, the EQ curve also had cuts. Sometimes cut rather than boost. It's a good rule to remember.
I can't remember my setup values as I have packed stuff away due to painting the house..... yeah, I know, shoot me in the head!..... otherwise I'd write them all down for you. If you do a search for 'EQ' or similar, or my username, I'm sure I've written them all down, but for 6L6 use. Of course, my settings may not suit you as your guitar, speaker, cabinets, etc, will make a huge difference in tone. But as a general read and maybe something to try, you've got nothing to lose, right?
EQ's will shape your tone more than any other pedal. IMO, highly recommended.