Thanks for the responses. Perhaps I can be a little more specific with my question and you guys can help me out:
I am currently in a band that plays "folk rock". Basically, there is an acoustic guitarist/singer, an electric lead (that's me), drummer, and a bassist. For rhythm work, I'm looking for an overdriven sound without too much distortion (high gain muddies the sound too much, even at 2 or 3 with the 12ax7). I have a TS-808 that I'm using for my leads but it's not quite the right sound for articulating chords over the acoustic. The comment above about the warmth of a 12at7 may be just what I'm looking for. Any other suggestions for getting a full, sustained, slightly distorted sound that won't overpower or otherwise ruin the folk-ish feel of a song? I'm not sure that I want to completely eliminate the possibility for high gain because I am in another project where heavy distortion is just what the doctor ordered.
Btw, I mostly use an SRV strat that's been modified with 50s and 60s pickups and a fatter neck, along with an Eric Clapton strat with gold lace pickups.