I play straight into the amp, no effects.
I use a lespaul studio with burstbuckers pro, a lespaul Menace, an SG faded equipped with 498/490, a LTD H400 with EMGs and a Yamaha RGX-A2 all through a Recto-Verb II with a 2X12 3/4 back and a 2X12 Recto cab.
I mostly play my own stuff, but also some...