i did what you are saying. you can also put the two tubes in the positions nearest to the rectifier tube and run the amp in 10w mode. i have a pair of rca 6V6s that i do this with from time to time.
i dont worry about changing the output load, since you are normally running a mismatch somewhere in the amp if you are using different wattage settings. but if you plan to use only 45 or only 10 then you can plug an 8 ohm load into your 4 ohm output.